Journal of the American Chemical Society

Novel, stable congeners of the antiretroviral compound 2', 3'-dideoxyadenosine

V Nair, GS Buenger

Index: Nair, Vasu; Buenger, Greg S. Journal of the American Chemical Society, 1989 , vol. 111, # 22 p. 8502 - 8504

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Citation Number: 85

Abstract

Abstract: Novel congeners of the antiretroviral compound 2', 3'-dideoxyadenosine (ddA) have been synthesized through metal-mediated and photochemical conversions as the key steps. These compounds are inherently more stable than ddA with respect to both glycosidic bond cleavage and deamination by adenosine deaminase.