The Alkylation of Amines with t-Acetylenic Chlorides. Preparation of Sterically Hindered Amines1

GF Hennion, RS Hanzel

Index: Hennion,G.F.; Hanzel,S. Journal of the American Chemical Society, 1960 , vol. 82, p. 4908 - 4912

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Citation Number: 56

Abstract

Discussion The successful alkylation of prim-and sec-amines by t-acetylenic chlorides was first reported in a previous paper in this series3 The present study was undertaken to determine if this reaction is applicable to amines RNHz and RR'NH of varied basicities and steric features; if the acetylenic amines, R1R2C (NRSR4) C= CH, so produced are amenable to semi-and full hydrogenation without hydrogenolysis; and thus to ascertain if ...