Base and copper (I) catalyzed Mannich, alkyne hydroamination cascades for the direct synthesis of 2-methylenepyrrolidines

HF Wang, T Yang, PF Xu, DJ Dixon

Index: Wang, Hai-Fei; Yang, Ting; Xu, Peng-Fei; Dixon, Darren J. Chemical Communications, 2009 , # 26 p. 3916 - 3918

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Abstract

Preliminary catalyst screening studies were performed using p-toluenesulfonyl imine 1a and malonate 2 in methanol at room temperature. A range of base and metal ion catalyst combinations were screened for overall performance (reaction efficiency and rate) and the results are presented in Table 1. Various combinations of strong bases (organic or inorganic) and copper complexes were soon identified as effective for the process and additional screening revealed ...