Synthesis and nuclear magnetic resonance study of 2-thiazolines

GL Eggleton, DR Bushman, DW Whitlock…

Index: Eggleton, Gordon L.; Bushman, Daniel R.; Whitlock, David W.; Pugh, Darrell K.; Chance, Katherine L. Journal of Chemical & Engineering Data, 1984 , vol. 29, # 3 p. 351 - 354

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Citation Number: 5

Abstract

Introduction A serles of 5, 5-dlmethyi-2-lhlazollne-4-carboxylates wlth a phenyl or methyl group at the 2-podtlon of the rlng were prepared from the correspondlng methyl or ethyl ester of penklllamlne and elther methyl benzlmldate or ethyl acetlmidate. The free acld was obtained by the reactlon of penlclllamlne wlth benzonltrlle to produce 5, 5-dlmethyl-2-phenyl- 2-thlasollne-4-carboxyllc acld. Correspondlng thiazollnes were prepared from cystelne In ...