The alkylation of isatin??derived oximes: Spectroscopic and X??ray crystallographic structural characterization of oxime and nitrone products

…, R Dalterio, R Rajamani, NA Meanwell

Index: Sin, Ny; Venables, Brian L.; Liu, Xiaohong; Huang, Stella; Gao, Qi; Ng, Alicia; Dalterio, Richard; Rajamani, Ramkumar; Meanwell, Nicholas A. Journal of Heterocyclic Chemistry, 2009 , vol. 46, # 3 p. 432 - 442

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Abstract

Oximes (1) are important synthetic intermediates in organic synthesis that have also found application in a medicinal chemistry setting. As a synthetically useful functionality, oximes can be used to protect carbonyl groups, reduced to an amine or, in the case of oximes derived from aldehydes, undergo dehydration to a nitrile [1]. During the course of our survey of small molecule inhibitors of respiratory syncytial virus (RSV) fusion, we were interested ...