Acetylenic and allenic derivatives of 2-(5-methoxyindolyl) methylamine: synthesis and evaluation as selective inhibitors of the monoamine oxidases A and B

MA Cruces, C Elorriaga, E Fernández-Alvarez…

Index: Cruces, M. A.; Elorriaga, C.; Fernandez-Alvarez, E.; Lopez, O. Nieto European Journal of Medicinal Chemistry, 1990 , vol. 25, # 3 p. 257 - 265

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Citation Number: 16

Abstract

Abstract A series of acetylenic and allenic derivatives of 2-(5-methoxyindolyl) methylamine has been synthesized. The new compounds were studied as inhibitors of the A and B forms of the mitochondrial monoamine oxidase (MAO) from bovine brain, using 14 C-tyramine as the substrate and clorgyline and l-deprenyl as references. All the studied compounds were MAO inhibitors. However, these compounds either did not show selectivity (compounds 3a ...