Synthesis of arylpiperazines via palladium-catalyzed aromatic amination reaction with unprotected piperazines

SH Zhao, AK Miller, J Berger, LA Flippin

Index: Zhao, Shu-Hai; Miller, Aubry K.; Berger, Jacob; Flippin, Lee A. Tetrahedron Letters, 1996 , vol. 37, # 26 p. 4463 - 4466

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Citation Number: 109

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of arylpiperazines were synthesized in moderate to good yields by palladium-catalyzed coupling reaction of aryl halides with unprotected piperazines. Very high regioselectivities were observed when using 2-methyl or 2,6-dimethylpiperazine. ... A series of arylpiperazines ...