Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2, 5-dimethoxyphenyl)-2-aminopropane

RA Glennon, R Young, F Benington…

Index: Glennon; Young; Benington; Morin Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1163 - 1168

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Citation Number: 68

Abstract

The serotonin (5-HT) receptor affiiities and behavioral (discriminative stimulus) properties of a series of 4-substituted derivatives of 1-(2, 5-dimethoxypheny1)-2-aminopropanes (2, 5- DMA) were investigated. The substituents at the 4-position included H, OMe, OEt, Me, Et, F, Br, I, and NOz. Substituent lipophilicities (T values) of these functionalities appear to have a minimal effect on either 5-HT receptor affinity or behavioral activity. Those derivatives ...