Removal of fluorine from and introduction of fluorine into polyhalopyridines: an exercise in nucleophilic hetarenic substitution

C Bobbio, T Rausis, M Schlosser

Index: Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910

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Citation Number: 29

Abstract

Abstract Starting from six industrially available fluorinated pyridines, an expedient access to all three tetrafluoropyridines (2–4), all six trifluoropyridines (5–10), and the five non- commercial difluoropyridines (11–14 and 16) was developed. The methods employed for the selective removal of fluorine from polyfluoropyridines were the reduction by metals or complex hydrides and the site-selective replacement by hydrazine followed by ...