Tetrahedron Letters

Palladium-catalyzed carbonylative coupling of benzyl chlorides with aryl boronic acids in aqueous media

XF Wu, H Neumann, M Beller

Index: Wu, Xiao-Feng; Neumann, Helfried; Beller, Matthias Tetrahedron Letters, 2010 , vol. 51, # 47 p. 6146 - 6149

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Citation Number: 37

Abstract

A novel chemoselective protocol for the carbonylative Suzuki coupling of benzyl chlorides with aryl boronic acids at low pressure of carbon monoxide has been developed. Applying a commercially available palladium acetate/PCy3 catalyst system in the presence of potassium phosphate as the base and water as the solvent the coupling reactions proceeded smoothly. To demonstrate the general applicability 12 different α-arylated ...

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