Amidines and related compounds. 6. Structure-activity relations of antihypertensive and antisecretory agents related to clonidine

T Jen, H Van Hoeven, W Groves…

Index: Jen,T. et al. Journal of Medicinal Chemistry, 1975 , vol. 18, p. 90 - 99

Full Text: HTML

Citation Number: 62

Abstract

Correlations of antihypertensive and antisecretory activities with various structural modifications of the antihypertensive agent clonidine [2-(2, 6-dichlorophenylimino) imidazolidine] are described. Eleven chemical classes of compounds containing an “amidine” moiety were prepared in this study. The antihypertensive activity of these compounds was evaluated in metacorticoid hypertensive rats and unanesthetized ...

Related Articles:

1, 10??Phenanthroline??Catalyzed Tandem Reaction of 2??Iodoanilines with Isothiocyanates in Water

[Zhang, Wu; Yue, Yun; Yu, Dan; Song, Lei; Xu, Yang-Yang; Tian, Yu-Jie; Guo, Yu-Jun Advanced Synthesis and Catalysis, 2012 , vol. 354, # 11-12 p. 2283 - 2287]

Cobalt??Catalyzed Oxidative Isocyanide Insertion to Amine??Based Bisnucleophiles: Diverse Synthesis of Substituted 2??Aminobenzimidazoles, 2??Aminobenzothiazoles …

[Zhu, Tong-Hao; Wang, Shun-Yi; Wang, Gao-Nan; Ji, Shun-Jun Chemistry - A European Journal, 2013 , vol. 19, # 19 p. 5850 - 5853]

More Articles...