Reaction of ascorbic acid with S-nitrosothiols: clear evidence for two distinct reaction pathways

AJ Holmes, DLH Williams

Index: Holmes, Anthony J.; Williams, D. Lyn H. Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 8 p. 1639 - 1644

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Citation Number: 100

Abstract

Ascorbate reacts with S-nitrosothiols generally, in the pH range 3–13 by way of two distinct pathways,(a) at low [ascorbate], typically below≈ 1× 10− 4 mol dm− 3 which leads to the formation of NO and the disulfide, and (b) at higher [ascorbate] when the products are the thiol and NO. Reaction (a) is Cu2+-dependent, and is completely cut out in the presence of EDTA, whereas reaction (b) is totally independent of [Cu2+] and takes place readily ...

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