Structure-activity studies of configurationally rigid arylprostaglandins

TK Schaaf, MR Johnson, JW Constantine…

Index: Schaaf; Johnson; Constantine; Bindra; Hess; Elger Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 328 - 334

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Citation Number: 10

Abstract

Potent, albeit nonselective, smooth-muscle stimulant activity has been previously reported for 16-phenoxy-and 17-phenylprostaglandins, a finding that led to the design and development of the tissue-selective uterine stimulant sulprostone. As an extension of this work, analogues incorporating the 16-phenoxy and 17-phenyl substituents into the rigid indanyl, tetrahydronaphthyl, dihydrobenzofuryl, and dihydrobenzopyranyl ring systems ...