Cationic chalcone antibiotics. Design, synthesis, and mechanism of action

SF Nielsen, M Larsen, T Boesen…

Index: Journal of Medicinal Chemistry, , vol. 48, # 7 p. 2667 - 2677

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Citation Number: 115

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. The chalcones described were all prepared by base-catalyzed Claisen−Schmidt condensation 22 of acetophenones with appropriate benzaldehydes (eg Scheme 3) in a yield of 2−73%. ...