Improved syntheses of 5′-S-(2-aminoethyl)-6-N-(4-nitrobenzyl)-5′-thioadenosine (SAENTA), analogues, and fluorescent probe conjugates: analysis of cell-surface …

…, D Mowles, G Barron, T Tackaberry…

Index: Robins, Morris J.; Peng, Yunshan; Damaraju, Vijaya L.; Mowles, Delores; Barron, Geraldine; Tackaberry, Tracey; Young, James D.; Cass, Carol E. Journal of Medicinal Chemistry, 2010 , vol. 53, # 16 p. 6040 - 6053

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Citation Number: 22

Abstract

5′-S-(2-Aminoethyl)-6-N-(4-nitrobenzyl)-5′-thioadenosine (SAENTA), 5′-S-(2- acetamidoethyl)-6-N-[(4-substituted) benzyl]-5′-thioadenosine analogues, 5′-S-[2-(6- aminohexanamido)] ethyl-6-N-(4-nitrobenzyl)-5′-thioadenosine (SAHENTA), and related compounds were synthesized by SNAr displacement of fluoride from 6-fluoropurine intermediates with 4-(substituted) benzylamines. Conjugation of the pendant amino ...