Nitroimidazole conjugates of bis (thiosemicarbazonato) 64 Cu (II)–Potential combination agents for the PET imaging of hypoxia

…, SR Bayly, MBM Theobald, HM Betts, JS Lewis…

Index: Bonnitcha, Paul D.; Bayly, Simon R.; Theobald, Mark B.M.; Betts, Helen M.; Lewis, Jason S.; Dilworth, Jonathan R. Journal of Inorganic Biochemistry, 2010 , vol. 104, # 2 p. 126 - 135

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Citation Number: 28

Abstract

Combination agents comprising two different pharmacophores with the same biological target have the potential to show additive or synergistic activity. Bis (thiosemicarbazonato) copper (II) complexes (eg 64Cu-ATSM) and nitroimidazoles (eg 18F-MISO) are classes of tracer used for the delineation of tumor hypoxia by positron emission tomography (PET). Three nitroimidazole-bis (thiosemicarbazonato) copper (II) conjugates were produced in ...