Functionalization of (2S)??Isopropyl??5??iodo??2, 3??dihydro??4 (H)??pyrimidin??4??ones by a Suzuki–Miyaura Cross??Coupling Reaction Using Aryltrifluoroborate Salts: …

…, G Reyes??Rangel, J Vargas??Caporali…

Index: Stefani, Helio A.; Amaral, Monica F. Z. J.; Reyes-Rangel, Gloria; Vargas-Caporali, Jorge; Juaristi, Eusebio European Journal of Organic Chemistry, 2010 , # 33 p. 6393 - 6403

Full Text: HTML

Citation Number: 5

Abstract

Abstract A simple protocol for the Pd (OAc) 2-catalyzed cross-coupling reaction of 1-benzoyl- (2S)-isopropyl-5-iodo-2, 3-dihydro-4 (H)-pyrimidin-4-ones with potassium aryltrifluoroborates was developed. The reaction is performed at 110 C with a ligand-free catalyst. In all cases, complete conversion of the 1-benzoyl-(2S)-isopropyl-5-iodo-2, 3- dihydro-4 (H)-pyrimidin-4-onesand aryltrifluoroborates into the C–C coupling products ...