Tetrahedron letters

Facile preparation of difluoromethyl-and monofluoromethyl-containing amides via Ritter reaction

J Liu, C Ni, Y Li, L Zhang, G Wang, J Hu

Index: Liu, Jun; Ni, Chuanfa; Li, Ya; Zhang, Laijun; Wang, Guanyu; Hu, Jinbo Tetrahedron Letters, 2006 , vol. 47, # 38 p. 6753 - 6756

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Citation Number: 21

Abstract

Both secondary and tertiary difluoromethylated carbinols were found to readily react with acetonitrile under the catalysis of concentrated sulfuric acid to give the corresponding difluoromethylated acetamides in good yields, which is remarkably more efficient than the previously reported Ritter reactions with corresponding trifluoromethylated carbinols. Similarly, monofluoromethylated and (benzenesulfonyl) difluoromethylated carbinols have ...