Stereoselective conversion of anhydrovinblastine into vinblastine utilizing an anti-vinblastine monoclonal antibody as a chiral mould

T Shirahama, T Kohno, T Kaijima, Y Nagaoka…

Index: Shirahama, Tatsuya; Kohno, Takeyuki; Kaijima, Tomohiro; Nagaoka, Yasuo; Morimoto, Daisuke; Hirata, Kazumasa; Uesato, Shinichi Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 5 p. 665 - 668

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Citation Number: 9

Abstract

Dimeric indole alkaloid, anhydrovinblastine, which can be obtained from catharanthine and vindoline in a high yield, was converted stereoselectively into vinblastine through alternating oxidation–reduction with oxygen and NaBH 3 CN in the presence of anti-vinblastine monoclonal antibody.

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