DBU Catalysis of N, N′-Carbonyldiimidazole-Mediated Amidations §

C Larrivée-Aboussafy, BP Jones, KE Price…

Index: Price, Kristin E.; Larrivee-Aboussafy, Claude; Lillie, Brett M.; McLaughlin, Robert W.; Mustakis, Jason; Hettenbach, Kevin W.; Hawkins, Joel M.; Vaidyanathan, Rajappa Organic Letters, 2009 , vol. 11, # 9 p. 2003 - 2006

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Citation Number: 35

Abstract

1, 8-Diazabicyclo [5.4. 0] undec-7-ene (DBU) has been found to catalyze the amidation of acyl imidazoles. The rate acceleration is especially evident with traditionally unreactive, electron-deficient anilines. DBU is readily available and offers safety and cost advantages over more commonly employed catalysts such as 1-hydroxybenzotriazole.