Novel Chemoenzymatic Synthesis of d (—)-Pantoyl Lactone

S Shimizu, H Yamada, H Hata, T Morishita…

Index: Shimizu, Sakayu; Yamada, Hideaki; Hata, Hiroyuki; Morishita, Tsuyoshi; Akutsu, Seiichi; Kawamura, Masao Agricultural and Biological Chemistry, 1987 , vol. 51, # 1 p. 289 - 290

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Citation Number: 38

Abstract

D (~)-Pantoyl lactone (R (-)-dihydro-3-hydroxy-4, 4-dimethyl-2 (3H)-furanone, Dl) is an important starting compound for the chemical synthesis of D (+)-pantothenic acid. The conventional synthetic process for Dl involves synthesis of racemic 1 from isobutyraldehyde, formaldehyde, and cyanide, and then optical resolution of the rademic 1. A disadvantage of this process, apart from the use of cyanide, is the troublesome resolution of the racemic 1. ...