Effect of Indole??3??Acetic Acid Analogs on the Differentiation of HL??60 Cells
JC Lien, YD Jiang, CJ Chen, SC Kuo…
Index: Lien, Jin-Cherng; Jiang, Yu-Dong; Chen, Chun-Jen; Kuo, Sheng-Chu; Huang, Li-Jiau Journal of the Chinese Chemical Society, 2008 , vol. 55, # 5 p. 1160 - 1165
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Citation Number: 4
Abstract
Abstract In continuing search for novel cell differentiation agents, a series of derivatives of indole-3-acetic acid and indole-3-carboxylic acid were prepared and tested against HL-60 cells for their differentiation and antiproliferation activities. Among them, N-ethyl-1- benzylindole-3-carboxamide (14) was the most potent, whereas N-methyl 1-benzylindole-3- acetamide (5) and N-methyl 1-benzylindole-3-carboxamide (13) synergistically ...
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