SYNTHESIS OF 1-BENZYL-3-[4-(ARYL-1-PIPERAZINYL) CARBONYL]-1H-INDOLES: NOVEL LIGANDS WITH POTENTIAL D4 DOPAMINERGIC ACTIVITY

…, CD PESSOA-MAHANA, R Araya-Maturana…

Index: Pessoa-Mahana, Hernan; Ignacio Cuevas; David Pessoa-Mahana; Araya-Maturana, Ramiro; Fajardo, Iriux Almodovar; Barria, Claudio Saitz Journal of the Chilean Chemical Society, 2011 , vol. 56, # 4 p. 866 - 869

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Citation Number: 2

Abstract

ABSTRACT The synthesis of a series of functionalized 1-Benzyl-3-[4-Aryl-1-piperazingl] carbonyl-1H-Indoles 6 (af), as a potential new class of bioactive ligands at D 4 receptors is reported. The synthetic strategy took place through a five steps sequence to provide indole amides 6 (af) in 75-92% yield.