2-(6-carboxyhexyl) cyclopentanone hexylhydrazone. A potent and time-dependent inhibitor of platelet aggregation

…, DL Venton, SC Hung, GC Le Breton

Index: Ghali; Venton; Hung; Le Breton Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 1056 - 1060

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Citation Number: 3

Abstract

Two new azaprostanoids, a hydrazone (3) and hydrazide (4), have been prepared by the condensation of 2-(6-carboxyhexy1) cyclopentanone with n-hexylhydrazine and caproic acid hydrazide. Preliminary results with the stable hydrazide 4 indicate that it inhibits arachidonic acid (AA) induced human platelet aggregation and that, unlike 13- azaprostanoic acid (l), ita site of action is at the cyclooxygenase level. Results with the ...