Synthesis and antifungal bioactivities of 3-alkylquinazolin-4-one derivatives

G Ouyang, P Zhang, G Xu, B Song, S Yang, L Jin…

Index: Ouyang, Guiping; Zhang, Peiquan; Xu, Gangfang; Song, Baoan; Yang, Song; Jin, Linhong; Xue, Wei; Hu, Deyu; Lu, Ping; Chen, Zhuo Molecules, 2006 , vol. 11, # 6 p. 383 - 392

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Citation Number: 57

Abstract

Abstract: A simple, efficient, and general method has been developed for the synthesis of various 3-alkylquinazolin-4-one derivatives from quinazolin-4-one treated with alkyl bromides under phase transfer catalysis condition. The structures of the compounds were characterized by elemental analysis, IR, 1 H-NMR and 13 C-NMR spectra. Title compound 6- bromo-3-propylquinazolin-4-one (3h) was found to possess good antifungal activity.