Inhibitors of Dengue virus and West Nile virus proteases based on the aminobenzamide scaffold

…, GH Lushington, EL Ferguson, R Padmanabhan…

Index: Aravapalli, Sridhar; Lai, Huiguo; Teramoto, Tadahisa; Alliston, Kevin R.; Lushington, Gerald H.; Ferguson, Eron L.; Padmanabhan; Groutas, William C. Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 13 p. 4140 - 4148

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Citation Number: 28

Abstract

Dengue and West Nile viruses (WNV) are mosquito-borne members of flaviviruses that cause significant morbidity and mortality. There is no approved vaccine or antiviral drugs for human use to date. In this study, a series of functionalized meta and para aminobenzamide derivatives were synthesized and subsequently screened in vitro against Dengue virus and West Nile virus proteases. Four active compounds were identified which showed ...

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