6-Substituted-5H-pyrrolo [2, 3-b] pyrazines via palladium-catalyzed heteroannulation from N-(3-chloropyrazin-2-yl)-methanesulfonamide and alkynes

CR Hopkins, N Collar

Index: Hopkins, Corey R.; Collar, Nicola Tetrahedron Letters, 2004 , vol. 45, # 43 p. 8087 - 8090

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Citation Number: 23

Abstract

We herein report the efficient and convenient synthesis of 6-substituted-5H-pyrrolo [2, 3-b] pyrazines. The reaction is a palladium-catalyzed heteroannulation process followed by deprotection to yield the desired pyrrolo [2, 3-b] pyrazine substrates. The reaction starts with readily accessible N-(3-chloropyrazin-2-yl)-methanesulfonamide and commercially available terminal alkynes and works with aryl-and alkylalkynes.