N2-(4-Substituted-2, 6-dichlorophenyl)-N1, N1-dimethylformamidines as antihypertensive and diuretic agents

WE Meyer, AS Tomcufcik, PS Chan…

Index: Meyer, Walter E.; Tomcufcik, Andrew S.; Chan, Peter S.; Emma, John E. Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1705 - 1710

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Citation Number: 4

Abstract

The synthesis of a series of fl-[4-[(arylmethyl) amino]-2, 6-dichlorophenyl]-~~- dimethylformamidines that caused marked blood pressure lowering and/or diuresis in spontaneously hypertensive rats (SHR) is reported. Diuretic activity was not always associated with acute antihypertensive activity. Central nervous system effects, most notably sedation, were observed. Compound 9d, which lowered arterial blood pressure 37 mmHg ...