7-Azetidinylquinolones as antibacterial agents. Synthesis and structure-activity relationships

…, J Corbera, D Vano, R Merce, A Torrens…

Index: Frigola; Pares; Corbera; Vano; Merce; Torrens; Mas; Valenti Journal of Medicinal Chemistry, 1993 , vol. 36, # 7 p. 801 - 810

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Citation Number: 65

Abstract

A series of novel antibacterial quinolones and naphthyridones has been prepared which contain 7-azetidinyl substituents in place of the usual piperazine or aminopyrrolidine groups. These azetidinyl derivatives were evaluated for in vitro activity by determining minimum inhibitory concentrations against a variety of bacteria. In vivo efficacy in the mouse infection model and blood levels in the mouse were determined for several compounds. The ...