Stereoselective synthesis of enantiopure N-protected-3-arylpiperazines from keto-esters

…, G Revelant, L Pelinski, F Agbossou-Niedercorn…

Index: Jida, Mouhamad; Laconde, Guillaume; Soueidan, Olivier-Mohamad; Lebegue, Nicolas; Revelant, Germain; Pelinski, Lydie; Agbossou-Niedercorn, Francine; Deprez, Benoit; Deprez-Poulain, Rebecca Tetrahedron Letters, 2012 , vol. 53, # 39 p. 5215 - 5218

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Citation Number: 4

Abstract

An efficient method for a stereoselective synthesis of optically pure N-Boc-3-arylpiperazines has been developed. After optimization of the protecting group strategy and experimental conditions, compounds were obtained via a highly stereoselective synthesis in up to 45% overall yield. This is a practical route to optically pure piperazines for medicinal chemistry.