Synthesis and antiviral activity evaluation of some novel acyclic C-nucleosides

N Lougiakis, P Marakos, N Poul…

Index: Lougiakis, Nikolaos; Marakos, Panagiotis; Poul, Nicole; Balzarini, Jan Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 6 p. 775 - 780

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Citation Number: 12

Abstract

The preparation of novel 5-amino or 7-hydroxy substituted pyrazolo [4, 3-b] pyridine and pyrazolo [3, 4-c] pyridine acyclic C-nucleosides is described. Their synthesis was carried out by condensation of suitably substituted lithiated picolines with 2- benzyloxyethoxymethylchloride followed by pyrazole ring annulation. The compounds were evaluated for their antiviral activity against a wide panel of viruses, but were found inactive ...