Tetrahedron letters

The Suzuki-Miyaura cross coupling reactions on solid support. Link to solution phase directed ortho metalation. The Leznoff acetal linker approach to biaryl and …

S Chamoin, S Houldsworth, CG Kruse, WI Bakker…

Index: Chamoin; Houldsworth; Kruse; Bakker, W. Iwema; Snieckus Tetrahedron Letters, 1998 , vol. 39, # 24 p. 4179 - 4182

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Citation Number: 72

Abstract

The synthesis of the titled compounds by Suzuki-Miyaura cross coupling on Merrifield resin— Leznoff acetal—linked halo benzaldehydes followed by mild acid hydrolysis is reported; synthetic utility for heterocycles based on solution phase Directed ortho Metalation chemistry is demonstrated.