Tetrahedron Letters

Gold (I)-catalyzed one-pot reaction between 2-alkynylanilines and alkynols leading to the formation of C-3-substituted indoles: a case of formal carboamination of …

NT Patil, V Singh, A Konala, AK Mutyala

Index: Patil, Nitin T.; Singh, Vipender; Konala, Ashok; Mutyala, Anil Kumar Tetrahedron Letters, 2010 , vol. 51, # 11 p. 1493 - 1496

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Citation Number: 33

Abstract

A process involving gold (I)-catalyzed formal carboamination of alkynes for the synthesis of C-3-substituted indoles has been developed. The procedure utilizes easily accessible starting materials such as 2-alkynylanilines and alkynols. A series of C-3-functionalized indoles are accessible by using this one-pot strategy. Mechanistically, the reaction involves three catalytic cycles and each of them is essentially catalyzed by a single metal catalyst, ...