Novel 2-(benzo [d] thiazol-2-yl)-1-(3-methyl-5-substituted-phenyl-4, 5-dihydropyrazol-1-yl) ethanone Derivatives: Synthesis and Antibacterial Activity

CX Pan, J Li, XH Liu

Index: Pan, Chun-Xiu; Lia, Jun; Liu, Xin-Hua Letters in Drug Design and Discovery, 2011 , vol. 8, # 5 p. 459 - 463

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Abstract

A series of novel 2-(benzo [d] thiazol-2-yl)-1-(3-methyl-5-substituted-phenyl-4, 5- dihydropyrazol-1-yl) ethanone derivatives were synthesized and characterized by NMR, ESI- MS. Biological activity tests results show that compounds 4a, 4b, 4d and 4g displayed activity with MIC of 1.562 μg/mL against B. subtilis ATCC 6633, compound 4d displayed significant activity with MIC of 1.562 μg/mL against S. aureus ATCC 6538. Compound 4a ...