Synthesis and structure-activity relationships of new arylfluoronaphthyridine antibacterial agents

…, PB Fernandes, AK Claiborne, EH Gracey…

Index: Chu, Daniel T. W.; Fernandes, Prabhavathi B.; Claiborne, Akiyo K.; Gracey, Eugene H.; Pernet, Andre G. Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2364 - 2369

Full Text: HTML

Citation Number: 72

Abstract

Novel ary~ uoro-1, 4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acids have been prepared and their antibacterial activity evaluated. These derivatives are characterized by having a fluorine atom at the 6-position, substituted amino groups at the 7-position, and substituted phenyl groups at the 1-position. The in vitro antibacterial potency is greatest when the 1-substituent is either p-fluorophenyl or opdifluorophenyl and the 7-substituent ...