Synthesis and GABA uptake inhibitory properties of 6-aryl iminoxymethyl substituted nipecotic acids

V N'Goka, TB Stenbøl, P Krogsgaard-Larsen…

Index: N'Goka, Victor; Stenbol, Tine B.; Krogsgaard-Larsen, Povl; Schlewer, Gilbert European Journal of Medicinal Chemistry, 2004 , vol. 39, # 10 p. 889 - 895

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Citation Number: 9

Abstract

Nipecotic acid derivatives bearing an aryl iminoxymethyl side chain at the position 6 were synthesised and tested for their GABA uptake inhibitory properties. Contrarily to the N- substituted derivatives 2, 3 the introduction of the oxime function in the side chain of analogues of the active nipecotic derivative 4 does neither increase, nor maintain the activity.