Divergent Synthesis and Evaluation of Inhibitory Activities against Cyclooxygenases-1 and-2 of Natural Withasomnines and Analogues

Y Usami, R Watanabe, Y Fujino, M Shibano…

Index: Usami, Yoshihide; Watanabe, Ryo; Fujino, Yuiko; Shibano, Makio; Ishida, Chihiro; Yoneyama, Hiroki; Harusawa, Shinya; Ichikawa, Hayato Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 12 p. 1550 - 1560

Full Text: HTML

Citation Number: 3

Abstract

The divergent synthesis of natural withasomnines and analogues was achieved from 4- hydroxypyrazoles, which was prepared via alkaline hydrolysis of the Baeyer–Villiger oxidation products from 4-formylpyrazoles. Key steps of this synthesis are regioselective Claisen rearrangement of 4-allyloxypyrazoles and the Suzuki–Miyaura coupling of 5, 6- dihydro-4H-pyrrolo [1, 2-b] pyrazol-3-yl trifluoromethanesulfonate and commercially ...

Related Articles:

Divergent synthesis of withasomnines via synthesis of 4-hydroxy-1H-pyrazoles and Claisen rearrangement of their 4-O-allylethers

[Ichikawa, Hayato; Watanabe, Ryo; Fujino, Yuiko; Usami, Yoshihide Tetrahedron Letters, 2011 , vol. 52, # 34 p. 4448 - 4451]

Regioselective Synthesis of Sulfonylpyrazoles via Base Mediated Reaction of Diazosulfones with Nitroalkenes and a Facile Entry into Withasomnine‡

[Kumar, Rahul; Namboothiri, Irishi N. N. Organic Letters, 2011 , vol. 13, # 15 p. 4016 - 4019]

Regioselective Synthesis of Sulfonylpyrazoles via Base Mediated Reaction of Diazosulfones with Nitroalkenes and a Facile Entry into Withasomnine‡

[Kumar, Rahul; Namboothiri, Irishi N. N. Organic Letters, 2011 , vol. 13, # 15 p. 4016 - 4019]

Regioselective Synthesis of Sulfonylpyrazoles via Base Mediated Reaction of Diazosulfones with Nitroalkenes and a Facile Entry into Withasomnine‡

[Kumar, Rahul; Namboothiri, Irishi N. N. Organic Letters, 2011 , vol. 13, # 15 p. 4016 - 4019]

Regioselective Synthesis of Sulfonylpyrazoles via Base Mediated Reaction of Diazosulfones with Nitroalkenes and a Facile Entry into Withasomnine‡

[Kumar, Rahul; Namboothiri, Irishi N. N. Organic Letters, 2011 , vol. 13, # 15 p. 4016 - 4019]

More Articles...