Synlett

Novel solid-phase synthetic method for combinatorial generation of a 4-hydroxyquinolin-2 (1H)-one-based library

MK Jeon, HJ La, DC Ha, YD Gong

Index: Jeon, Moon-Kook; Hyun, Ju La; Ha, Deok-Chan; Gong, Young-Dae Synlett, 2007 , # 9 p. 1431 - 1435

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Citation Number: 4

Abstract

Abstract Utilizing polymer-bound anthranilic acid derivatives, we were able to obtain 4- hydroxyquinolin-2 (1H)-ones in 50-99% five-or six-step overall yields and 65-95% purities through the adaptation of a Dieckmann-type condensation reaction to a CC bond-forming cyclative cleavage step. The reactions on solid phase were monitored by on-bead ATR-FTIR spectroscopic methods, colorimetric tests, and/or cleavage experiments.