Design, synthesis, and biological evaluation of novel 4-hydro-quinoline-3-carboxamide derivatives as an immunomodulator

JF He, LH Yun, RF Yang, ZY Xiao, JP Cheng…

Index: He, Jun-Feng; Yun, Liu-Hong; Yang, Ri-Fang; Xiao, Zhi-Yong; Cheng, Jun-Ping; Zhou, Wen-Xia; Zhang, Yong-Xiang Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 12 p. 2980 - 2985

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Citation Number: 28

Abstract

A series of novel quinoline-3-carboxamide derivatives were synthesized and evaluated for their immunomodulatory activity. The compounds were tested in vitro for effects on spleen lymphocyte proliferation and TNF-α production by macrophage. Three compounds showed immunomodulatory profiles similar to and more potent than those of linomide and FR137316 and were selected for further pharmacological studies in vivo.