Aminomethylation of chiral silyl enol ethers: access to β 2-homotryptophane and β 2-homolysine derivatives

…, M Larregola, Y Boutadla, S Lavielle, P Karoyan

Index: Moumne, Roba; Larregola, Maud; Boutadla, Youcef; Lavielle, Solange; Karoyan, Philippe Tetrahedron Letters, 2008 , vol. 49, # 32 p. 4704 - 4707

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Citation Number: 10

Abstract

We describe here the aminomethylation of chiral silyl enol ether derivatives using iminium ion. The choice of judicious precursors with adequate protecting groups for the silylation/ aminomethylation step was required to achieve the synthesis of β2-homotryptophane in few steps. The same methodology was used to prepare a β2-homolysine derivative.

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