Synthesis and pharmacological properties of 1, 2, 3-substituted 1, 2, 3, 4-tetrahydro-β-carbolines

…, AS Melik-Ogandzhanyan, RR Safrazbekyan…

Index: Pogosyan, S. A.; Matevosyan, L. A.; Melik-Ogandzhanyan, A. S.; Safrazbekyan, R. R.; Arzanunts, E. M.; et al. Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 10 p. 714 - 717 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 10 p. 1191 - 1195

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Abstract

The condensation of I with aldehyde II was carried out by heating equimolar amounts of the components in boiling water in the presence of 2 NH= SO,. The structure of 8-carboline III was confirmed by IR and PMR spectra, and also by the negative Ehrlich color reaction, indicating the absence of a free 2-position in the indole ring. In the IR spectrum there is an absorption band at 1620 cm-:, characteristic for an aromatic ring and an absorption band ...