Synthesis and antiviral activity of carbocyclic analogs of xylofuranosides of 2-amino-6-substituted-purines and 2-amino-6-substituted-8-azapurines

R Vince, RH Turakhia, WM Shannon…

Index: Vince; Turakhia; Shannon; Arnett Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 2026 - 2030

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Citation Number: 30

Abstract

Department of Medicinal Chemistry, College of Pharmacy, Health Sciences Unit F, University of Minnesota, Minneapolis, Minnesota 55455, and Southern Research Institute, Birmingham, Alabama 35255. Received May 28, 1987 (*)-(la, 2P, 30, 5a)-3-[(2, 5-Diamino-6- chloro-4-pyrimidinyl) amino]-5-(hydroxymethyl)-l, 2-cyclopentanediol (7) was synthesized from 2-amino-4, 6-dichloropyrimidine and the carbocyclic xylofuranosylamine (A)-(la, 2@, ...