Novel 1β-methylcarbapenems with isoxazoloethenyl moieties containing carboxylic acid sodium salt

KS Lee, YK Kang, KH Yoo, DC Kim, KJ Shin…

Index: Lee, Kyung Seok; Kang, Yong Koo; Yoo, Kyung Ho; Kim, Dong Chan; Shin, Kye Jung; Paik, Young-Sook; Kim, Dong Jin Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 231 - 234

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Citation Number: 9

Abstract

The synthesis of novel 1β-methylcarbapenems 1a, b having sodium 5-(3-and 5-carboxylic acid) isoxazoloethenyl moieties at C-5 position of pyrrolidine ring and their biological evaluation are described. Both compounds showed potent and well-balanced antibacterial activity as well as high stability to DHP-I. The selected sodium 3-carboxylic acid derivative 1a possessed excellent DHP-I stability and advanced pharmacokinetic parameters in ...