Enantioselective, chromatography-free synthesis of β3-amino acids with natural and unnatural side chains

T Gerfaud, YL Chiang, I Kreituss…

Index: Gerfaud, Thibaud; Chiang, Ying-Ling; Kreituss, Imants; Russak, Justin A.; Bode, Jeffrey W. Organic Process Research and Development, 2012 , vol. 16, # 4 p. 687 - 696

Full Text: HTML

Citation Number: 9

Abstract

β3-Amino acids are key components of some pharmaceuticals, excellent surrogates for metabolically labile α-amino acids, and building blocks for chiral heterocycles. Unfortunately they are not easily accessible in enantiomerically pure form, especially when possessing unnatural side chains. A flexible, chromatography-free process for the synthesis of enantiopure β3-amino acids possessing natural and unnatural side chains is described. ...

Related Articles:

A formylcarbonium ion synthon. Synthesis of 3-thio-substituted 2-amino acids and thio-substituted enamines from 2-acyloxyacrylonitriles

[Oku, Akira; Hori-ie, Naofumi; Harada, Toshiro Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 2 p. 609 - 612]

A formylcarbonium ion synthon. Synthesis of 3-thio-substituted 2-amino acids and thio-substituted enamines from 2-acyloxyacrylonitriles

[Oku, Akira; Hori-ie, Naofumi; Harada, Toshiro Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 2 p. 609 - 612]

A formylcarbonium ion synthon. Synthesis of 3-thio-substituted 2-amino acids and thio-substituted enamines from 2-acyloxyacrylonitriles

[Oku, Akira; Hori-ie, Naofumi; Harada, Toshiro Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 2 p. 609 - 612]

A formylcarbonium ion synthon. Synthesis of 3-thio-substituted 2-amino acids and thio-substituted enamines from 2-acyloxyacrylonitriles

[Oku, Akira; Hori-ie, Naofumi; Harada, Toshiro Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 2 p. 609 - 612]

More Articles...