Semisynthetic. BETA.-lactam antibiotics. IV. Synthesis and antibacterial activity of new ureidocephalosporin and ureidocephamycin derivatives containing a catechol …

…, M MATSUMOTO, H OKAZAKI, I MATSUNAGA

Index: Ohi; Aoki; Shinozaki; Moro; Kuroki; Noto; Nehashi; Matsumoto; Okazaki; Matsunaga Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 5 p. 1903 - 1909

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Citation Number: 18

Abstract

New ureidocephalosporin and ureidocephamycin derivatives containing a catechol moiety or its acetate were prepared and their minimum inhibitory concentration values against various microorganisms were determined. Among these compounds, the ureidocephalosporins (2, 3Aa, 3Ba) and ureidocephamycins (4, 5) carrying a methyl group on the nitrogen atom of the ureido bond showed strong activities against Pseudomonas ...