Intramolecular nickel catalyzed cycloadditions of bis-dienes: 3 approaches to the taxane skeleton

PA Wender, ML Snapper

Index: Wender, Paul A.; Snapper, Marc L. Tetrahedron Letters, 1987 , vol. 28, # 20 p. 2221 - 2224

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Citation Number: 83

Abstract

Abstract The successful application of the nickel catalyzed, intramolecular [4+ 4] cycloaddition of bis-dienes to the preparation of both the AB and BC ring systems of the taxane diterpenes is described. This cycloaddition methodology provides the basis for a general and efficient route to angularly alkyl-substituted bicyclo [6.4. 0] dodecanes and to bicyclo [5.3. 1] undecanes.