Tetrahedron

Synthesis of the phthalide-containing anti-Helicobacter pylori agents CJ-13,015, CJ-13,102, CJ-13,103, CJ-13,104 and CJ-13,108

MA Brimble, CL Flowers, JK Hutchinson, JE Robinson…

Index: Brimble, Margaret A.; Flowers, Christopher L.; Hutchinson, James K.; Robinson, James E.; Sidford, Matthew Tetrahedron, 2005 , vol. 61, # 42 p. 10036 - 10047

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Citation Number: 14

Abstract

Flexible racemic syntheses of the phthalide-containing antibiotics CJ-13,015, CJ-13,102, CJ- 13,103, CJ-13,104 and CJ-13,108 that inhibit Helicobacter pylori have been carried out in a convergent fashion by Wittig coupling of a phthalide-containing aldehyde fragment with an appropriate phosphorous ylide.

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