Studies on histaminergic compounds VIII. A new series of compounds showing H1-antagonistic and H2-agonistic properties; synthesis, in vitro pharmacology and …

…, J Koper, H Van Der Goot, H Timmerman

Index: Sterk; Koper; Van Der Goot; Timmerman European Journal of Medicinal Chemistry, 1987 , vol. 22, # 6 p. 491 - 498

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Citation Number: 14

Abstract

Abstract To study the structure—activity relationships (SAR) of impromidine-like H 2- agonists, we prepared some analogues of the potent agonist VUF 8405 (an analogue of impromidine in which the 5-methylimidazole moiety was replaced by a phenyl group) by replacing the benzyl group of VUF 8405 with substituted diphenylmethyl moieties and a number of related groups. The compounds have been tested for H 1-activity on guinea pig ...