Nucleophilic trifluoromethylation of anhydrides employing (trifluoromethyl) trimethylsilane: Synthesis of γ-trifluoromethylated γ-butyrolactones

…, D Soorukram, C Kuhakarn, P Tuchinda…

Index: Masusai, Chonticha; Soorukram, Darunee; Kuhakarn, Chutima; Tuchinda, Patoomratana; Reutrakul, Vichai; Pohmakotr, Manat Journal of Fluorine Chemistry, 2013 , vol. 154, p. 37 - 42

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Citation Number: 7

Abstract

Abstract Fluoride-catalyzed nucleophilic trifluoromethylation of acid anhydrides using CF 3 SiMe 3 provided the corresponding γ-hydroxy-γ-trifluoromethyl-γ-butyrolactones. The utility of these adducts was further demonstrated by treatment with Grignard reagents, leading to γ- trifluoromethylated γ-butyrolactones.