Thiaisatoic anhydrides: efficient synthesis under microwave heating conditions and study of their reactivity

F Fabis, S Jolivet-Fouchet, M Robba, H Landelle…

Index: Fabis, Frederic; Jolivet-Fouchet, Sandrine; Robba, Max; Landelle, Henriette; Rault, Sylvain Tetrahedron, 1998 , vol. 54, # 36 p. 10789 - 10800

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Citation Number: 27

Abstract

2-thiaisatoic anhydride 1 and 3-thiaisatoic anhydride 2 were synthesized in large scale under microwave heating conditions with 85% and 67% yields respectively. The reactivity of these two compounds was studied towards various nucleophiles and appeared to be generally different from that of isatoic anhydride: many new thiophene-2 and 3-carboxylic acids were isolated with good yields as potential new pharmacological scaffolds.